Summary: Visual cortical plasticity is high during early life. but gradually decreases with development. This is due to the Otx2-driven maturation of intracortical inhibition that parallels the condensation of extracellular matrix components into perineuronal nets mainly around parvalbumin-positive GABAergic neurons. Repressor Element 1 Silencing Transcription (REST) epigenetically co... https://www.chiggate.com/satisfyer-pro-penguin-next-generation-on-sale/