This mechanism, generally known as presynaptic inhibition, happens when a postsynaptic neuron releases endocannabinoids in retrograde transmission, which then bind to cannabinoid receptors within the presynaptic terminal. CB1 receptors then minimize the amount of neurotransmitter released, so that subsequent excitation from the presynaptic neuron brings about diminished effects within... https://jaredpdjpt.therainblog.com/32014115/little-known-facts-about-psychoactive-effects